Journal: ACS Measurement Science Au

Article Title: Optimizing Solid Microneedle Design: A Comprehensive ML-Augmented DOE Approach

doi: 10.1021/acsmeasuresciau.4c00021

Figure Lengend Snippet: Flowchart illustrates the analysis and optimization process for four distinct MN designs; cone and tapered shaped and square and pyramidal base shaped. Step 0 involved subjecting the MNs to three loading conditions: compressive load during insertion, critical buckling load, and bending loading due to wrong insertion. Step 1 involved transferring the model into a set of input–output links such that a matrix correlation can be built, representing the relationship of what parameters can affect these analyses. Step 2 included the sampling the design space of the data using a sampling algorithm for the DOE. Step 3 provided a training procedure of DOE data to be fitted into the regression models. The regression model was able to produce the response surface curve, the sensitivity chart, and the prediction models such that no further FEA runs are needed. According to the obtained results in step 3, optimization through RSO was executed using multiobjective algorithms, step 4. The geometrical results of the optimization were validated using the computation model of FEA, step 5. Finally, a GUI was created to serve as a user-friendly mode for testing and exploring new design patterns, step 6.

Article Snippet: This framework systematically links the inputs and outputs as a mathematical model through the available response surface fitting models in the ANSYS workbench, including machine learning (ML) algorithms for regression fitting.

Techniques: Transferring, Sampling